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Instrument: Vasco, Wallis
Industry: Nanomedicine
DOI: https://doi.org/10.1016/j.jpba.2018.01.052
Keywords: 177Lu, Carbon nanospheres, NGR peptide, DOTA, Tumor vasculature, Theranostic
This study explores the potential of 177Lu-labeled carbon nanospheres as radio-nanoprobes for molecular imaging and therapy. The carboxyl functionalized surface of carbon nanospheres (CNS) was conjugated with [Gly-Gly-Gly-c(Asn-Gly-Arg)], G3-cNGR peptide through amide bond for targeting tumor vasculature and with [2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid], p-NH2-Bz-DOTA for chelation with 177Lu.