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Instrument: Vasco Kin
Industry: Cell Biology
DOI: https://doi.org/10.1101/2021.12.03.471088
Keywords: intrinsically disordered protein, lipid-protein interaction, membrane transport, phospholipid vesicle, circular dichroism (CD), membrane curvature, amphipathic helix, lipid packing
Tumor Protein D54 (TPD54) is an abundant cytosolic protein that belongs to the TPD52 family, a family of four proteins (TPD52, 53, 54 and 55) that are overexpressed in several cancer cells. Even though the functions of these proteins remain elusive, recent investigations indicate that TPD54 binds to very small cytosolic vesicles with a diameter of ca. 30 nm, half the size of classical transport vesicles (e.g. COPI and COPII). (360)