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NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction

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Industry: Nanomedicine
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Instrument: Vasco, Wallis

Industry: Nanomedicine

DOI: https://doi.org/10.3390/antiox11050847

Keywords: endothelial dysfunction; calcium; cyclic stretch; human pulmonary artery endothelial cells; nickel oxide nanoparticles; mitochondria alteration; reactive oxygen species

The development and use of nanomaterials, especially of nickel oxide nanoparticles (NiONPs), is expected to provide many benefits but also has raised concerns about the potential human health risks. Inhaled NPs are known to exert deleterious cardiovascular side effects, including pulmonary hypertension. (263 characters)
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