In the present study, the several novel beads, multi-stimuli responsive were designed based on CMC-ECH-CTS with various CMC/CTS ratio 1:1, 1:2 and 2:1 (S1–S3) to survey the targeted delivery and the triggered release of the model drugs. The reaction was done in the presence of %0.01, %0.018 and 0.025 %wt Fe3O4 MNPs (S4–S9) and also in the absence of Fe3O4 MNPs. (303 characters)